NFL PREDICTION, COLTS VS TITANS! 09/21/2025, JIMMY RED ALERT!
- Ghost Picks Jimmy Blog
- Sep 21
- 2 min read
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The Colts roll into this AFC South matchup as 5 point favorites over the Titans, and for good reason, Indy’s offense has looked efficient behind Daniel Jones with Jonathan Taylor anchoring the run game, while the Titans, rookie QB Cam Ward is still adjusting behind a shaky offensive line that just lost key starter JC Latham. Tennessee’s defense has been vulnerable against the run, which is a bad matchup against Taylor, and with DT T’Vondre Sweat also out, Indy should control the trenches. The Titans have shown flashes but remain inconsistent, while the Colts are healthier. This is going to come down to capacity and the Colts are set up for success in this one.
Colts -5
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